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KMID : 1100220040030020111
Dementia and Neurocognitive Disorders
2004 Volume.3 No. 2 p.111 ~ p.116
Behavioral and Psychological Symptoms in Frontotemporal Dementia
Kang Sue-Jin

Lee Byung-Hwa
Kim Eun-Joo
Park Key-Chung
Na Duk-Lyul
Abstract
Background: Frontotemporal dementia (FTD) usually presents with behavioral and psychological symptoms of dementia (BPSD) rather than cognitive deficits. Thus, understanding of BPSD associated with FTD is important not only from the management perspective but also from the diagnostic viewpoint. However, few studies have investigated BPSD in patients with FTD in Korea. The aim of the current study is to describe in detail BPSD associated with FTD.

Methods: Firstly, a BPSD list was designed based on the symptoms reported in previous studies of FTD, items from the Neuropsychiatric Inventory (NPI), and the review of medical records of FTD patients from our clinic including FTD patients not selected in this study. Then an interviewer asked caregivers whether the BPSDs listed had been present from onset of disease to the time of interview. Subjects who participated in the interview consisted of 23 patients (9 men and 14 women) with a mean age of 65.6 (range, 41-75) years who met the FTD criteria proposed by the Lund and Manchester group. The BPSD list was completed by face-to-face interviews or by telephone interviews with the caregivers.

Results: BPSDs as classified by subscales of the NPI in the order of frequency were aberrant motor behavior (95.6%), apathy (95.6%), disinhibition (91.3%), appetite/eating change (91.3%), agitation/aggression (87%), euphoria (65.2%), anxiety (60.9%), irritability/lability (52.1%), delusions (43.5%), night-time behavior (39.1%), depression/dysphoria (34.8%), hallucinations (0%). Other symptoms not listed in the NPI were stereotypical behaviors as stereotypy of ordering, hoarding, reading signboards, wandering a fixed route, washing, and counting, utilization behaviors, and sundowning.

Conclusion: Our detailed description of BPSD associated with Korean FTD patients would help understand symptoms of FTD and develop a Korean version of BPSD questionnaire for FTD in the future studies.
KEYWORD
Frontotemporal dementia (FTD), Neuropsychiatric inventory (NPI), Behavioral and psychological symptoms of dementia (BPSD)
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